Crystal structure of a family VIII β‐lactamase fold hydrolase reveals the molecular mechanism for its broad substrate scope

Family VIII esterases present similarities to class C β‐lactamases, which show nucleophilic serines located at the S‐X‐X‐K motif instead of the G‐X‐S‐X‐G or G‐D‐S‐(L) motif shown by other carboxylesterase families. Here, we report the crystal structure of a novel family VIII (subfamily VIII. I) este...

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Detalles Bibliográficos
Autores principales: Cea‐Rama, Isabel, Coscolín, Cristina, Gonzalez‐Alfonso, Jose L., Raj, Jog, Vasiljević, Marko, Plou, Francisco J., Ferrer, Manuel, Sanz‐Aparicio, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795927/
https://www.ncbi.nlm.nih.gov/pubmed/35694902
http://dx.doi.org/10.1111/febs.16554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795927/
https://www.ncbi.nlm.nih.gov/pubmed/35694902
http://dx.doi.org/10.1111/febs.16554

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