Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study

Selective voltage‐gated sodium channel blockers are of growing interest as treatment for pain. For drug development of such compounds, it would be critical to have a biomarker that can be used for proof‐of‐mechanism. We aimed to evaluate whether drug‐induced changes in sodium conductance can be dete...

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Detalles Bibliográficos
Autores principales: Ruijs, Titia Q., Koopmans, Ingrid W., de Kam, Marieke L., van Esdonk, Michiel J., Koltzenburg, Martin, Groeneveld, Geert Jan, Heuberger, Jules A.A.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795956/
https://www.ncbi.nlm.nih.gov/pubmed/35762293
http://dx.doi.org/10.1002/cpt.2694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795956/
https://www.ncbi.nlm.nih.gov/pubmed/35762293
http://dx.doi.org/10.1002/cpt.2694

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