Comparative Bioavailability of a Single Dose of Trametinib (TMT212) Containing 9% vs 11% Dimethyl Sulfoxide in Randomized Healthy Volunteers to Assess Long‐Term Storage at Room Temperature

Storage of trametinib tablets outside of 2‐8°C protected from moisture may lead to loss of dimethyl sulfoxide (DMSO) and adversely impact trametinib bioavailability. In this open‐label, phase 1, single‐dose, randomized, 2‐treatment, 2‐period crossover study in healthy volunteers, bioavailability of...

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Detalles Bibliográficos
Autores principales: Tan, Eugene Y., Chiparus, Ovidiu, Choudhury, Somesh, Kim, Christina, Lau, Mike, Ziltener, Christoph, Ilankumaran, Palanichamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796035/
https://www.ncbi.nlm.nih.gov/pubmed/35736001
http://dx.doi.org/10.1002/cpdd.1129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796035/
https://www.ncbi.nlm.nih.gov/pubmed/35736001
http://dx.doi.org/10.1002/cpdd.1129

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