An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice

BACKGROUND: Respiratory syncytial virus (RSV) is a leading viral respiratory pathogen in infants. The objective of this study was to generate RSV live-attenuated vaccine (LAV) candidates by removing the G-protein mucin domains to attenuate viral replication while retaining immunogenicity through des...

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Detalles Bibliográficos
Autores principales: Roe, Molly K, Perez, Maria A, Hsiao, Hui-Mien, Lapp, Stacey A, Sun, He-Ying, Jadhao, Samadhan, Young, Audrey R, Batista, Yara S, Reed, Ryan C, Taz, Azmain, Piantadosi, Anne, Chen, Xuemin, Liang, Bo, Koval, Michael, Snider, Timothy A, Moore, Martin L, Anderson, Evan J, Anderson, Larry J, Stobart, Christopher C, Rostad, Christina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796166/
https://www.ncbi.nlm.nih.gov/pubmed/36281651
http://dx.doi.org/10.1093/infdis/jiac382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796166/
https://www.ncbi.nlm.nih.gov/pubmed/36281651
http://dx.doi.org/10.1093/infdis/jiac382

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