Intranasal M2SR (M2-Deficient Single Replication) H3N2 Influenza Vaccine Provides Enhanced Mucosal and Serum Antibodies in Adults

BACKGROUND: We previously demonstrated that an intranasal dose of 10(8) 50% tissue culture infectious dose (TCID(50)) M2-deficient single replication (M2SR) influenza vaccine protected against highly drifted H3N2 influenza challenge in a subset of subjects who demonstrated ≥2-fold increase in micron...

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Detalles Bibliográficos
Autores principales: Eiden, Joseph, Fierro, Carlos, Schwartz, Howard, Adams, Mark, Ellis, Kimberly J, Aitchison, Roger, Herber, Renee, Hatta, Yasuko, Marshall, David, Moser, Michael J, Belshe, Robert, Greenberg, Harry, Coelingh, Kathleen, Kawaoka, Yoshihiro, Neumann, Gabriele, Bilsel, Pamuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796169/
https://www.ncbi.nlm.nih.gov/pubmed/36350017
http://dx.doi.org/10.1093/infdis/jiac433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796169/
https://www.ncbi.nlm.nih.gov/pubmed/36350017
http://dx.doi.org/10.1093/infdis/jiac433

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