Activation of p53: How phosphorylated Ser15 triggers sequential phosphorylation of p53 at Thr18 by CK1δ

The N‐terminal transactivation domain (TAD) of p53 is a disordered region with multiple phosphorylation sites. Phosphorylation at Thr18 is crucial for the release of p53 from its negative regulator, MDM2. In stressed cells, CK1δ is responsible for phosphorylating Thr18, but requires Ser15 to be phos...

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Detalles Bibliográficos
Autores principales: Nicolaou, Sonia T., Kannan, Srinivasaraghavan, Warwicker, Jim, Verma, Chandra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796392/
https://www.ncbi.nlm.nih.gov/pubmed/35752942
http://dx.doi.org/10.1002/prot.26393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796392/
https://www.ncbi.nlm.nih.gov/pubmed/35752942
http://dx.doi.org/10.1002/prot.26393

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