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The pharmacology of blinatumomab: state of the art on pharmacodynamics, pharmacokinetics, adverse drug reactions and evaluation in clinical trials

WHAT IS KNOWN AND OBJECTIVE: Bispecific drugs (BDs) belong to the family of immunotherapies along with checkpoint inhibitors and CAR‐T cells. In the field of oncology, BDs are designed to simultaneously bind a tumour antigen on the one side and an antigen present on the surface of effector cells on...

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Detalles Bibliográficos
Autores principales: Mocquot, Pauline, Mossazadeh, Yasmine, Lapierre, Léopoldine, Pineau, Fanny, Despas, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796714/
https://www.ncbi.nlm.nih.gov/pubmed/35906791
http://dx.doi.org/10.1111/jcpt.13741