Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2

Much remains to be determined about the participation of ubiquitin receptors in proteasomal degradation and their potential as therapeutic targets. Suppression of the ubiquitin receptor S5A/PSMD4/hRpn10 alone stabilises p53/TP53 but not the key p53 repressor MDM2. Here, we observed S5A and the ubiqu...

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Detalles Bibliográficos
Autores principales: Sparks, Alison, Kelly, Christopher J., Saville, Mark K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796813/
https://www.ncbi.nlm.nih.gov/pubmed/35735670
http://dx.doi.org/10.1002/1873-3468.14436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796813/
https://www.ncbi.nlm.nih.gov/pubmed/35735670
http://dx.doi.org/10.1002/1873-3468.14436

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