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Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat

Human angiotensin I‐converting enzyme (ACE) has two isoforms, somatic ACE (sACE) and testis ACE (tACE). The functions of sACE are widespread, with its involvement in blood pressure regulation most extensively studied. sACE is composed of an N‐domain (nACE) and a C‐domain (cACE), both catalytically a...

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Detalles Bibliográficos
Autores principales: Cozier, Gyles E., Newby, Emma C., Schwager, Sylva L. U., Isaac, R. Elwyn, Sturrock, Edward D., Acharya, K. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796954/
https://www.ncbi.nlm.nih.gov/pubmed/35653492
http://dx.doi.org/10.1111/febs.16543