Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes

Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial fluid viscosity, and pro-inflammatory cytokine c...

Descripción completa

Detalles Bibliográficos
Autores principales: Pendyala, Meghana, Woods, Paige S., Brubaker, Douglas K., Blaber, Elizabeth A., Schmidt, Tannin A., Chan, Deva D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797074/
https://www.ncbi.nlm.nih.gov/pubmed/36576921
http://dx.doi.org/10.1371/journal.pone.0267921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797074/
https://www.ncbi.nlm.nih.gov/pubmed/36576921
http://dx.doi.org/10.1371/journal.pone.0267921

Ejemplares similares