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Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial fluid viscosity, and pro-inflammatory cytokine c...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797074/ https://www.ncbi.nlm.nih.gov/pubmed/36576921 http://dx.doi.org/10.1371/journal.pone.0267921 |