Cargando…

Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

BACKGROUND: Airway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)-β has been known to promote epithelial-mesenchymal transition formation and to play a role in the progression of tissue fibrosis. Cellular communication network factor 2 (CCN2) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Wun-Hao, Kao, Shih-Ya, Chen, Chia-Ling, Yuliani, Fara Silvia, Lin, Lee-Yuan, Lin, Chien-Huang, Chen, Bing-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797108/ https://www.ncbi.nlm.nih.gov/pubmed/36578010 http://dx.doi.org/10.1186/s12931-022-02285-2

Ejemplares similares

Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells
por: Yuliani, Fara Silvia, et al.
Publicado: (2022)

Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19
por: Maranatha, Daniel, et al.
Publicado: (2022)

Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin
por: Coniglio, Salvatore J., et al.
Publicado: (2021)

Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts
por: Purohit, Trupta, et al.
Publicado: (2017)

The Amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
por: Raugh, Arielle, et al.
Publicado: (2023)

The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
por: Raugh, Arielle, et al.
Publicado: (2023)

Spatial Gradients of E-Cadherin and Fibronectin in TGF-β1-Treated Epithelial Colonies Are Independent of Fibronectin Fibril Assembly
por: Griggs, Lauren A., et al.
Publicado: (2023)

CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation
por: Tejera-Muñoz, Antonio, et al.
Publicado: (2021)

Oncogenic signaling in amphiregulin and EGFR‐expressing PTEN‐null human breast cancer
por: Kappler, Christiana S., et al.
Publicado: (2014)

The induction of CCN2 by TGFβ1 involves Ets-1
por: Van Beek, Jonathan P, et al.
Publicado: (2006)

Positive feedback of the amphiregulin-EGFR-ERK pathway mediates PM2.5 from wood smoke-induced MUC5AC expression in epithelial cells
por: Huang, Lingmei, et al.
Publicado: (2017)

High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia
por: Heriyanto, Didik Setyo, et al.
Publicado: (2022)

Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases
por: Platen, Christopher, et al.
Publicado: (2018)

Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway
por: Taverna, Simona, et al.
Publicado: (2017)

CCN5 Reduces Ligamentum Flavum Hypertrophy by Modulating the TGF‐β Pathway
por: Ye, Sunghyeok, et al.
Publicado: (2019)

CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression
por: Chen, Po-Chun, et al.
Publicado: (2017)

EGF, TGF-α and Amphiregulin Differently Regulate Endometrium-Derived Mesenchymal Stromal/Stem Cells
por: Kamentseva, Rimma Sergeevna, et al.
Publicado: (2023)

Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma
por: Huang, Yu-Wen, et al.
Publicado: (2020)

Correction: Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts
Publicado: (2017)

TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways
por: Ou, Shu-Ching, et al.
Publicado: (2020)

IGF-1 Counteracts TGF-β-Mediated Enhancement of Fibronectin for in Vitro Human Lens Epithelial Cells
por: Chung, So-Hyang, et al.
Publicado: (2007)

Amphiregulin Regulates Melanocytic Senescence
por: Pommer, Michaela, et al.
Publicado: (2021)

TAZ sensitizes EGFR wild-type non-small-cell lung cancer to gefitinib by promoting amphiregulin transcription
por: Yuan, Weiwei, et al.
Publicado: (2019)

Atractylodin Suppresses TGF-β-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
por: Chang, Kai-Wei, et al.
Publicado: (2021)

The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway
por: Xue, Xiang, et al.
Publicado: (2015)

CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation
por: Chang, C-C, et al.
Publicado: (2013)

Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and the Bcl-2 Protein Family
por: Platen, Christopher, et al.
Publicado: (2019)

CCN2 Binds to Tubular Epithelial Cells in the Kidney
por: Rayego-Mateos, Sandra, et al.
Publicado: (2022)

Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex
por: Hua, Hung-Sheng, et al.
Publicado: (2023)

Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon
Publicado: (1992)

Hepsin regulates TGFβ signaling via fibronectin proteolysis
por: Belitškin, Denis, et al.
Publicado: (2021)

Lipopolysaccharide-induced CCN1 production enhances interleukin-6 secretion in bronchial epithelial cells
por: Shi, Lin, et al.
Publicado: (2017)

Expression of Amphiregulin in Enchondromas and Central Chondrosarcomas
por: Losada, Daniele Moraes, et al.
Publicado: (2021)

Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro
por: Mendes, Fabio A., et al.
Publicado: (2015)

Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis
por: MacDonald, Iona J., et al.
Publicado: (2021)

Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes
por: Zhu, Ji, et al.
Publicado: (2012)

Abnormal amphiregulin expression correlates with gastric cancer prognosis
por: Wang, Bing, et al.
Publicado: (2016)

AFAP1 Is a Novel Downstream Mediator of TGF-β1 for CCN2 Induction in Osteoblasts
por: Cho, Youngjin, et al.
Publicado: (2015)

Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma
por: Wu, Yu-Ying, et al.
Publicado: (2023)

BMP-7 Attenuates TGF-β1-Induced Fibronectin Secretion and Apoptosis of NRK-52E Cells by the Suppression of miRNA-21
por: Yu, Zhong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hlqb9jh3gshp2ns6vi97bdhhso