Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome

BACKGROUND: Acute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and a rash with a neutrophilic infiltrate. The disease pathophysiology remains elusive, and current dogma suggests that Sweet syndrome is a...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Shreya, Basu, Sayon, Sheng, Emily, Murphy, Christina, Wei, Jenny, Kersh, Anna E., Nelson, Caroline A., Bryer, Joshua S., Ashchyan, Hovik A., Steele, Katherine, Forrestel, Amy, Seykora, John T., Micheletti, Robert G., James, William D., Rosenbach, Misha, Leung, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797331/
https://www.ncbi.nlm.nih.gov/pubmed/36355435
http://dx.doi.org/10.1172/JCI162137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797331/
https://www.ncbi.nlm.nih.gov/pubmed/36355435
http://dx.doi.org/10.1172/JCI162137

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