The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with Notch4 expression on Tregs, here, we show that Tregs in MIS-...

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Detalles Bibliográficos
Autores principales: Benamar, Mehdi, Chen, Qian, Chou, Janet, Julé, Amélie M., Boudra, Rafik, Contini, Paola, Crestani, Elena, Lai, Peggy S., Wang, Muyun, Fong, Jason, Rockwitz, Shira, Lee, Pui, Chan, Tsz Man Fion, Altun, Ekin Zeynep, Kepenekli, Eda, Karakoc-Aydiner, Elif, Ozen, Ahmet, Boran, Perran, Aygun, Fatih, Onal, Pinar, Sakalli, Ayse Ayzit Kilinc, Cokugras, Haluk, Gelmez, Metin Yusuf, Oktelik, Fatma Betul, Cetin, Esin Aktas, Zhong, Yuelin, Taylor, Maria Lucia, Irby, Katherine, Halasa, Natasha B., Mack, Elizabeth H., Signa, Sara, Prigione, Ignazia, Gattorno, Marco, Cotugno, Nicola, Amodio, Donato, Geha, Raif S., Son, Mary Beth, Newburger, Jane, Agrawal, Pankaj B., Volpi, Stefano, Palma, Paolo, Kiykim, Ayca, Randolph, Adrienne G., Deniz, Gunnur, Baris, Safa, De Palma, Raffaele, Schmitz-Abe, Klaus, Charbonnier, Louis-Marie, Henderson, Lauren A., Chatila, Talal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797337/
https://www.ncbi.nlm.nih.gov/pubmed/36282598
http://dx.doi.org/10.1172/JCI163235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797337/
https://www.ncbi.nlm.nih.gov/pubmed/36282598
http://dx.doi.org/10.1172/JCI163235

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