Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8(+) T cells

Accumulation of activated immune cells results in nonspecific hepatocyte killing in chronic hepatitis B (CHB), leading to fibrosis and cirrhosis. This study aims to understand the underlying mechanisms in humans and to define whether these are driven by widespread activation or a subpopulation of im...

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Detalles Bibliográficos
Autores principales: Nkongolo, Shirin, Mahamed, Deeqa, Kuipery, Adrian, Sanchez Vasquez, Juan D., Kim, Samuel C., Mehrotra, Aman, Patel, Anjali, Hu, Christine, McGilvray, Ian, Feld, Jordan J., Fung, Scott, Chen, Diana, Wallin, Jeffrey J., Gaggar, Anuj, Janssen, Harry L.A., Gehring, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797343/
https://www.ncbi.nlm.nih.gov/pubmed/36594467
http://dx.doi.org/10.1172/JCI158903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797343/
https://www.ncbi.nlm.nih.gov/pubmed/36594467
http://dx.doi.org/10.1172/JCI158903

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