IL-10-producing Th1 cells possess a distinct molecular signature in malaria

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Control of intracellular parasites responsible for malaria requires host IFN-γ(+)T-bet(+)CD4(+) T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response. However, these IL-10–producing Th1 (induced type I regulatory [Tr1]) cells can also pr...

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Detalles Bibliográficos
Autores principales: Edwards, Chelsea L., Ng, Susanna S., de Labastida Rivera, Fabian, Corvino, Dillon, Engel, Jessica A., Montes de Oca, Marcela, Bukali, Luzia, Frame, Teija C.M., Bunn, Patrick T., Chauhan, Shashi Bhushan, Singh, Siddharth Sankar, Wang, Yulin, Na, Jinrui, Amante, Fiona H., Loughland, Jessica R., Soon, Megan S.F., Waddell, Nicola, Mukhopadhay, Pamela, Koufariotis, Lambros T., Johnston, Rebecca L., Lee, Jason S., Kuns, Rachel, Zhang, Ping, Boyle, Michelle J., Hill, Geoffrey R., McCarthy, James S., Kumar, Rajiv, Engwerda, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797345/
https://www.ncbi.nlm.nih.gov/pubmed/36594463
http://dx.doi.org/10.1172/JCI153733
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