RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP). SASP is mediated by the activation of cytoplasmic nucleic acid sensors. However, the molecular mechanism underlying the...

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Detalles Bibliográficos
Autores principales: Sugawara, Sho, Okada, Ryo, Loo, Tze Mun, Tanaka, Hisamichi, Miyata, Kenichi, Chiba, Masatomo, Kawasaki, Hiroko, Katoh, Kaoru, Kaji, Shizuo, Maezawa, Yoshiro, Yokote, Koutaro, Nakayama, Mizuho, Oshima, Masanobu, Nagao, Koji, Obuse, Chikashi, Nagayama, Satoshi, Takubo, Keiyo, Nakanishi, Akira, Kanemaki, Masato T., Hara, Eiji, Takahashi, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797495/
https://www.ncbi.nlm.nih.gov/pubmed/36577784
http://dx.doi.org/10.1038/s42003-022-04369-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797495/
https://www.ncbi.nlm.nih.gov/pubmed/36577784
http://dx.doi.org/10.1038/s42003-022-04369-7

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