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Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein
The complement system is one of the first defense lines protecting from invading pathogens. However, it may turn offensive to the body’s own cells and tissues when deregulated by the presence of rare genetic variants that impair physiological regulation and/or provoke abnormal activity of key enzyma...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797810/ https://www.ncbi.nlm.nih.gov/pubmed/36591303 http://dx.doi.org/10.3389/fimmu.2022.1061696 |