Cargando…

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells

P2X7 receptor (P2RX7) is expressed strongly by most human cancers, including neuroblastoma, where high levels of P2RX7 are correlated with a poor prognosis for patients. Tonic activation of P2X7 receptor favors cell metabolism and angiogenesis, thereby promoting cancer cell proliferation, immunosupp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benito-León, María, Gil-Redondo, Juan Carlos, Perez-Sen, Raquel, Delicado, Esmerilda G., Ortega, Felipe, Gomez-Villafuertes, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797830/ https://www.ncbi.nlm.nih.gov/pubmed/36589747 http://dx.doi.org/10.3389/fcell.2022.1049566

Ejemplares similares

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells
por: Pérez-Sen, Raquel, et al.
Publicado: (2019)

Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability
por: Chen, Hsueh-Fen, et al.
Publicado: (2019)

P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling
por: Queipo, Mª José, et al.
Publicado: (2018)

Dusp4 Contributes to Anesthesia Neurotoxicity via Mediated Neural Differentiation in Primates
por: Yan, Jia, et al.
Publicado: (2020)

DUSP4 phosphatase puts the brakes on DLBCL
por: Rickert, Robert
Publicado: (2015)

DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
por: Amand, Mathieu, et al.
Publicado: (2014)

Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance
por: Singh, Mithalesh K., et al.
Publicado: (2022)

Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer’s disease
por: Wang, Erming, et al.
Publicado: (2023)

The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity
por: Jiménez-Martínez, Marta, et al.
Publicado: (2019)

Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway
por: Ha, Jain, et al.
Publicado: (2019)

DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
por: Wang, Zheng, et al.
Publicado: (2010)

Involvement of the Cellular Phosphatase DUSP1 in Vaccinia Virus Infection
por: Cáceres, Ana, et al.
Publicado: (2013)

Revisiting the roles of VHR/DUSP3 phosphatase in human diseases
por: Russo, Lilian Cristina, et al.
Publicado: (2018)

A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth
por: Thevenon, Dominique, et al.
Publicado: (2020)

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability
por: Russo, Lilian C., et al.
Publicado: (2021)

Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids
por: Shipp, Lauren E., et al.
Publicado: (2010)

Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement
por: Zuchegna, Candida, et al.
Publicado: (2020)

Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia
por: Chen, Lauren L, et al.
Publicado: (2019)

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
por: Buffet, Camille, et al.
Publicado: (2017)

Expression of Dual-Specificity Phosphatase 5 Pseudogene 1 (DUSP5P1) in Tumor Cells
por: Staege, Martin S., et al.
Publicado: (2014)

DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases
por: Khoubai, Fatma Zohra, et al.
Publicado: (2021)

Nucleotide-Induced Nanoscale Changes in the Mechanical Properties of Rat Cerebellar Astrocytes: Selective Stimulation and Blocking of the Purinergic Receptor P2X7 †
por: Gil-Redondo, Juan Carlos, et al.
Publicado: (2022)

DUSPs, to MAP kinases and beyond
por: Huang, Ching-Yu, et al.
Publicado: (2012)

The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes
por: Tischer, Thomas, et al.
Publicado: (2016)

DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases
por: Ding, Tao, et al.
Publicado: (2019)

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
por: Ge, Chenxu, et al.
Publicado: (2022)

The Dual-Specificity Phosphatase 2 (DUSP2) Does Not Regulate Obesity-Associated Inflammation or Insulin Resistance in Mice
por: Lancaster, Graeme I., et al.
Publicado: (2014)

Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer
por: Ahmad, Muhammad Khairi, et al.
Publicado: (2018)

Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma
por: Gupta, Avinash, et al.
Publicado: (2019)

A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding
por: Shillingford, Shanelle, et al.
Publicado: (2022)

LncRNA TCONS_00145741 Knockdown Prevents Thrombin-Induced M1 Differentiation of Microglia in Intracerebral Hemorrhage by Enhancing the Interaction Between DUSP6 and JNK
por: Wu, Lanxiang, et al.
Publicado: (2022)

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
por: Perander, Maria, et al.
Publicado: (2017)

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea
por: Bermúdez-Muñoz, Jose M., et al.
Publicado: (2021)

DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma
por: Ju, Gaoda, et al.
Publicado: (2021)

Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT) in the Central Nervous System: Relevance of the Vesicular Nucleotide Release as a Potential Therapeutic Target
por: Miras-Portugal, María T., et al.
Publicado: (2019)

NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis
por: Shi, Y, et al.
Publicado: (2015)

Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes
por: Mélard, Pierre, et al.
Publicado: (2016)

Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis
por: Zhao, Zandong, et al.
Publicado: (2021)

The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth
por: Kim, Hyunjoo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1pjo6k6bjk0n9aojh9d052t9f5