Cargando…

Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank

Nonalcoholic fatty liver disease is common and highly heritable. Genetic studies of hepatic fat have not sufficiently addressed non-European and rare variants. In a medical biobank, we quantitate hepatic fat from clinical computed tomography (CT) scans via deep learning in 10,283 participants with w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Joseph, MacLean, Matthew T., Lucas, Anastasia M., Torigian, Drew A., Schneider, Carolin V., Cherlin, Tess, Xiao, Brenda, Miller, Jason E., Bradford, Yuki, Judy, Renae L., Verma, Anurag, Damrauer, Scott M., Ritchie, Marylyn D., Witschey, Walter R., Rader, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798024/ https://www.ncbi.nlm.nih.gov/pubmed/36513072 http://dx.doi.org/10.1016/j.xcrm.2022.100855

Ejemplares similares

The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population
por: Verma, Anurag, et al.
Publicado: (2022)

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank
por: Wang, Louise, et al.
Publicado: (2022)

Genetics of height and risk of atrial fibrillation: A Mendelian randomization study
por: Levin, Michael G., et al.
Publicado: (2020)

A simulation study investigating power estimates in phenome-wide association studies
por: Verma, Anurag, et al.
Publicado: (2018)

Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies
por: Li, Binglan, et al.
Publicado: (2019)

Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population
por: Verma, Shefali S., et al.
Publicado: (2022)

Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression()
por: Li, Binglan, et al.
Publicado: (2018)

Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records
por: Crosslin, David R., et al.
Publicado: (2014)

Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202
por: Verma, Anurag, et al.
Publicado: (2017)

Exome sequencing and characterization of 49,960 individuals in the UK Biobank
por: Van Hout, Cristopher V., et al.
Publicado: (2020)

Exome sequencing and analysis of 454,787 UK Biobank participants
por: Backman, Joshua D., et al.
Publicado: (2021)

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases
por: Verma, Anurag, et al.
Publicado: (2016)

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort
por: Zaidi, Arslan A., et al.
Publicado: (2023)

Exome Sequencing–Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants
por: Manickam, Kandamurugu, et al.
Publicado: (2018)

Rare variant contribution to human disease in 281,104 UK Biobank exomes
por: Wang, Quanli, et al.
Publicado: (2021)

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults
por: Li, Binglan, et al.
Publicado: (2021)

Exome-wide evidence of compound heterozygous effects across common phenotypes in the UK Biobank
por: Lassen, Frederik H., et al.
Publicado: (2023)

Relationships between body fat distribution and metabolic syndrome traits and outcomes: A mendelian randomization study
por: Huang, Brian, et al.
Publicado: (2023)

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank
por: Hofmeister, Robin J., et al.
Publicado: (2023)

Exome sequencing reveals a high prevalence of BRCA1 and BRCA2 founder variants in a diverse population-based biobank
por: Abul-Husn, Noura S., et al.
Publicado: (2019)

Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort
por: Schneider, Carolin V., et al.
Publicado: (2021)

Another Round of “Clue” to Uncover the Mystery of Complex Traits
por: Verma, Shefali Setia, et al.
Publicado: (2018)

Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank
por: Wuttke, Matthias, et al.
Publicado: (2023)

Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss
por: Henne, Sabrina Katrin, et al.
Publicado: (2023)

Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes
por: Tsao, Noah L., et al.
Publicado: (2023)

SUN-032 Exome Sequencing Reveals that Pathogenic RET Variants Occur at Higher Prevalence Than Previously Recognized: Data from a US Health System Biobank
por: Guzman, Heidi, et al.
Publicado: (2019)

A unified framework identifies novel links between plasma lipids and diseases from electronic medical records across large-scale cohorts
por: Veturi, Yogasudha, et al.
Publicado: (2021)

A Network-Based Analysis of Disease Complication Associations for Obstetric Disorders in the UK Biobank
por: Sriram, Vivek, et al.
Publicado: (2021)

Has the biobank bubble burst? Withstanding the challenges for sustainable biobanking in the digital era
por: Chalmers, Don, et al.
Publicado: (2016)

Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain*
por: Keat, Karl, et al.
Publicado: (2023)

Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses
por: Barton, Alison R., et al.
Publicado: (2021)

Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
por: Karczewski, Konrad J., et al.
Publicado: (2022)

Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes
por: Wendt, Frank R., et al.
Publicado: (2022)

Reliability and validity of the UK Biobank cognitive tests
por: Fawns-Ritchie, Chloe, et al.
Publicado: (2020)

eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants
por: Verma, Anurag, et al.
Publicado: (2016)

Primary retroperitoneal mature cystic teratoma with focal enteric type adenocarcinoma in a post-partum woman: report of a case with literature review
por: Hong, Wei, et al.
Publicado: (2013)

eQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals
por: Drivas, Theodore G., et al.
Publicado: (2021)

Rare GATA6 variants associated with risk of congenital heart disease phenotypes in 200,000 UK Biobank exomes
por: Williams, Simon G., et al.
Publicado: (2021)

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
por: Fawcett, Katherine A., et al.
Publicado: (2022)

Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants
por: Curtis, David
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vn8bb56r5p9v1g4fhdavv08kpb