Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates

Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a Palladium/NIXANTPHOS-based catalyst system was developed. This approach furnishes a variety of substituted...

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Autores principales: Jiang, Yonggang, Wang, Bijun, Liu, Dongxiang, Xia, Dazhen, Liu, Zhengfen, Li, Liang, Deng, Guogang, Yang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798101/
https://www.ncbi.nlm.nih.gov/pubmed/36590282
http://dx.doi.org/10.3389/fchem.2022.1091566
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author Jiang, Yonggang
Wang, Bijun
Liu, Dongxiang
Xia, Dazhen
Liu, Zhengfen
Li, Liang
Deng, Guogang
Yang, Xiaodong
author_facet Jiang, Yonggang
Wang, Bijun
Liu, Dongxiang
Xia, Dazhen
Liu, Zhengfen
Li, Liang
Deng, Guogang
Yang, Xiaodong
author_sort Jiang, Yonggang
collection PubMed
description Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a Palladium/NIXANTPHOS-based catalyst system was developed. This approach furnishes a variety of substituted and functionalized aryl acrylonitriles (up to 95% yield). The scalability of the transformation and the synthetic versatility of aryl acrylonitrile were demonstrated.
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spelling pubmed-97981012022-12-30 Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates Jiang, Yonggang Wang, Bijun Liu, Dongxiang Xia, Dazhen Liu, Zhengfen Li, Liang Deng, Guogang Yang, Xiaodong Front Chem Chemistry Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a Palladium/NIXANTPHOS-based catalyst system was developed. This approach furnishes a variety of substituted and functionalized aryl acrylonitriles (up to 95% yield). The scalability of the transformation and the synthetic versatility of aryl acrylonitrile were demonstrated. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9798101/ /pubmed/36590282 http://dx.doi.org/10.3389/fchem.2022.1091566 Text en Copyright © 2022 Jiang, Wang, Liu, Xia, Liu, Li, Deng and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Jiang, Yonggang
Wang, Bijun
Liu, Dongxiang
Xia, Dazhen
Liu, Zhengfen
Li, Liang
Deng, Guogang
Yang, Xiaodong
Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
title Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
title_full Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
title_fullStr Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
title_full_unstemmed Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
title_short Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
title_sort aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798101/
https://www.ncbi.nlm.nih.gov/pubmed/36590282
http://dx.doi.org/10.3389/fchem.2022.1091566
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