Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines

Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always fully modified. Combinations and permutations of p...

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Detalles Bibliográficos
Autores principales: Pichot, Florian, Hogg, Marion C., Marchand, Virginie, Bourguignon, Valérie, Jirström, Elisabeth, Farrell, Cliona, Gibriel, Hesham A., Prehn, Jochen H.M., Motorin, Yuri, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798144/
https://www.ncbi.nlm.nih.gov/pubmed/36618980
http://dx.doi.org/10.1016/j.csbj.2022.12.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798144/
https://www.ncbi.nlm.nih.gov/pubmed/36618980
http://dx.doi.org/10.1016/j.csbj.2022.12.020

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