The MECP2‐TRD domain interacts with the DNMT3A‐ADD domain at the H3‐tail binding site

The DNMT3A DNA methyltransferase and MECP2 methylation reader are highly expressed in neurons. Both proteins interact via their DNMT3A‐ADD and MECP2‐TRD domains, and the MECP2 interaction regulates the activity and subnuclear localization of DNMT3A. Here, we mapped the interface of both domains usin...

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Detalles Bibliográficos
Autores principales: Kunert, Stefan, Linhard, Verena, Weirich, Sara, Choudalakis, Michel, Osswald, Florian, Krämer, Lisa, Köhler, Anja R., Bröhm, Alexander, Wollenhaupt, Jan, Schwalbe, Harald, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798253/
https://www.ncbi.nlm.nih.gov/pubmed/36519786
http://dx.doi.org/10.1002/pro.4542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798253/
https://www.ncbi.nlm.nih.gov/pubmed/36519786
http://dx.doi.org/10.1002/pro.4542

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