Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters

Tuberculosis (TB) is an infectious disease that occurs globally. Treatment of TB has been hindered by problems with multidrug-resistant strains (MDR-TB). Fluoroquinolones are one of the main drugs used for the treatment of MDR-TB. The success of therapy can be influenced by genetic factors and their...

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Autores principales: Annisa, Nurul, Barliana, Melisa I., Santoso, Prayudi, Ruslami, Rovina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798452/
https://www.ncbi.nlm.nih.gov/pubmed/36588725
http://dx.doi.org/10.3389/fphar.2022.1063413
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author Annisa, Nurul
Barliana, Melisa I.
Santoso, Prayudi
Ruslami, Rovina
author_facet Annisa, Nurul
Barliana, Melisa I.
Santoso, Prayudi
Ruslami, Rovina
author_sort Annisa, Nurul
collection PubMed
description Tuberculosis (TB) is an infectious disease that occurs globally. Treatment of TB has been hindered by problems with multidrug-resistant strains (MDR-TB). Fluoroquinolones are one of the main drugs used for the treatment of MDR-TB. The success of therapy can be influenced by genetic factors and their impact on pharmacokinetic parameters. This review was conducted by searching the PubMed database with keywords polymorphism and fluoroquinolones. The presence of gene polymorphisms, including UGT1A1, UGT1A9, SLCO1B1, and ABCB1, can affect fluoroquinolones pharmacokinetic parameters such as area under the curve (AUC), creatinine clearance (C(Cr)), maximum plasma concentration (C(max)), half-life (t(1/2)) and peak time (t(max)) of fluoroquinolones.
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spelling pubmed-97984522022-12-30 Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters Annisa, Nurul Barliana, Melisa I. Santoso, Prayudi Ruslami, Rovina Front Pharmacol Pharmacology Tuberculosis (TB) is an infectious disease that occurs globally. Treatment of TB has been hindered by problems with multidrug-resistant strains (MDR-TB). Fluoroquinolones are one of the main drugs used for the treatment of MDR-TB. The success of therapy can be influenced by genetic factors and their impact on pharmacokinetic parameters. This review was conducted by searching the PubMed database with keywords polymorphism and fluoroquinolones. The presence of gene polymorphisms, including UGT1A1, UGT1A9, SLCO1B1, and ABCB1, can affect fluoroquinolones pharmacokinetic parameters such as area under the curve (AUC), creatinine clearance (C(Cr)), maximum plasma concentration (C(max)), half-life (t(1/2)) and peak time (t(max)) of fluoroquinolones. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9798452/ /pubmed/36588725 http://dx.doi.org/10.3389/fphar.2022.1063413 Text en Copyright © 2022 Annisa, Barliana, Santoso and Ruslami. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Annisa, Nurul
Barliana, Melisa I.
Santoso, Prayudi
Ruslami, Rovina
Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
title Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
title_full Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
title_fullStr Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
title_full_unstemmed Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
title_short Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
title_sort transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798452/
https://www.ncbi.nlm.nih.gov/pubmed/36588725
http://dx.doi.org/10.3389/fphar.2022.1063413
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