Using a Mathematical Modeling To Simulate Pharmacokinetics and Urinary Glucose Excretion of Luseogliflozin and Explore the Role of SGLT1/2 in Renal Glucose Reabsorption

[Image: see text] (1) Purpose: To develop a mathematical model combining physiologically based pharmacokinetic and urinary glucose excretion (PBPK-UGE) to simultaneously predict pharmacokinetic (PK) and UGE changes of luseogliflozin (LUS) as well as to explore the role of sodium-glucose cotransporte...

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Detalles Bibliográficos
Autores principales: Wang, Zhongjian, Wang, Guopeng, Ren, Jiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798748/
https://www.ncbi.nlm.nih.gov/pubmed/36591124
http://dx.doi.org/10.1021/acsomega.2c06483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798748/
https://www.ncbi.nlm.nih.gov/pubmed/36591124
http://dx.doi.org/10.1021/acsomega.2c06483

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