Identification and semisynthesis of (−)-anisomelic acid as oral agent against SARS-CoV-2 in mice

(−)-Anisomelic acid, isolated from Anisomeles indica (L.) Kuntze (Labiatae) leaves, is a macrocyclic cembranolide with a trans-fused α-methylene-γ-lactone motif. Anisomelic acid effectively inhibits SARS-CoV-2 replication and viral-induced cytopathic effects with an EC(50) of 1.1 and 4.3 μM, respect...

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Detalles Bibliográficos
Autores principales: Yu, Hai-Xin, Zheng, Nan, Yeh, Chi-Tai, Lee, Chien-Ming, Zhang, Qi, Zheng, Wen-Lv, Chang, Qing, Li, Yuan-He, Li, Yu-Jun, Wu, Gui-Zhen, Quan, Jun-Min, Zhang, Lin-Qi, Tzeng, Yew-Min, Yang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RESEARCH ARTICLE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798891/
https://www.ncbi.nlm.nih.gov/pubmed/36601138
http://dx.doi.org/10.1093/nsr/nwac176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798891/
https://www.ncbi.nlm.nih.gov/pubmed/36601138
http://dx.doi.org/10.1093/nsr/nwac176

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