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Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors

BACKGROUND: Neuroinflammation in the nucleus accumbens (NAc) is well known to influence the progression of depression. However, the molecular mechanisms triggering NAc neuroinflammation in depression have not been fully elucidated. Progranulin (PGRN) is a multifunctional growth factor that is linked...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Lai, Simin, Zhou, Ting, Xia, Zhihao, Li, Weina, Sha, Wenqi, Liu, Jingjie, Chen, Yanjiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798954/
https://www.ncbi.nlm.nih.gov/pubmed/36581897
http://dx.doi.org/10.1186/s12974-022-02684-8