Cargando…

Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension

AIMS: Pulmonary arterial hypertension (PAH) is a fatal disease without a cure. Previously, we found that transcription factor RUNX1-dependent haematopoietic transformation of endothelial progenitor cells may contribute to the pathogenesis of PAH. However, the therapeutic potential of RUNX1 inhibitio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Euy-Myoung, Pereira, Mandy, So, Eui-Young, Wu, Keith Q, Del Tatto, Michael, Wen, Sicheng, Dooner, Mark S, Dubielecka, Patrycja M, Reginato, Anthony M, Ventetuolo, Corey E, Quesenberry, Peter J, Klinger, James R, Liang, Olin D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799056/ https://www.ncbi.nlm.nih.gov/pubmed/35018410 http://dx.doi.org/10.1093/cvr/cvac001

Ejemplares similares

Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice
por: So, Eui-Young, et al.
Publicado: (2020)

Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model
por: Aliotta, Jason M., et al.
Publicado: (2017)

Effect of dose, dosing intervals, and hypoxic stress on the reversal of pulmonary hypertension by mesenchymal stem cell extracellular vesicles
por: Klinger, James R, et al.
Publicado: (2021)

Biodistribution of Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Radiation Injury Bone Marrow Murine Model
por: Wen, Sicheng, et al.
Publicado: (2019)

Differentiation Epitopes Define Hematopoietic Stem Cells and Change with Cell Cycle Passage
por: Goldberg, Laura R., et al.
Publicado: (2022)

Lipid phosphatase SHIP‐1 regulates chondrocyte hypertrophy and skeletal development
por: So, Eui‐Young, et al.
Publicado: (2019)

Low dose 100 cGy irradiation as a potential therapy for pulmonary hypertension
por: Egan, Pamela C., et al.
Publicado: (2019)

Daily rhythms influence the ability of lung-derived extracellular vesicles to modulate bone marrow cell phenotype
por: Dooner, Mark S., et al.
Publicado: (2018)

Light at the ENDothelium-role of Sox17 and Runx1 in endothelial dysfunction and pulmonary arterial hypertension
por: Simmons Beck, Robert, et al.
Publicado: (2023)

Mesenchymal stromal cell derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells
por: Wen, Sicheng, et al.
Publicado: (2016)

Lung-derived exosome uptake into and epigenetic modulation of marrow progenitor/stem and differentiated cells
por: Aliotta, Jason M., et al.
Publicado: (2015)

The role of salivary vesicles as a potential inflammatory biomarker to detect traumatic brain injury in mixed martial artists
por: Matuk, Rani, et al.
Publicado: (2021)

The universal stem cell
por: Quesenberry, Peter J., et al.
Publicado: (2022)

Prime Time for Proteomics in Pulmonary Arterial Hypertension Risk Assessment?
por: Singh, Navneet, et al.
Publicado: (2022)

Another Piece in the Estrogen Puzzle of Pulmonary Hypertension
por: Al-Naamani, Nadine, et al.
Publicado: (2020)

The Modified Borg Dyspnea Scale does not predict hospitalization in pulmonary arterial hypertension
por: Banerjee, Debasree, et al.
Publicado: (2017)

Murine Leukemia-Derived Extracellular Vesicles Elicit Antitumor Immune Response
por: Pando, Alejandro, et al.
Publicado: (2021)

NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
por: Oh, Amy, et al.
Publicado: (2023)

Marrow Hematopoietic Stem Cells Revisited: They Exist in a Continuum and are Not Defined by Standard Purification Approaches; Then There are the Microvesicles
por: Quesenberry, Peter J., et al.
Publicado: (2014)

Heuristic bias in stem cell biology
por: Quesenberry, Peter, et al.
Publicado: (2019)

Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma
por: Cheng, Yan, et al.
Publicado: (2019)

Prevalence and risk factors of pulmonary hypertension among adult patients with HIV infection in Ethiopia
por: Huluka, Dawit Kebede, et al.
Publicado: (2020)

Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension
por: Sun, Xiuna, et al.
Publicado: (2022)

Experimental design of the Effects of Dehydroepiandrosterone in Pulmonary Hypertension (EDIPHY) trial
por: Walsh, Thomas P., et al.
Publicado: (2021)

Stable cell fate changes in marrow cells induced by lung-derived microvesicles
por: Aliotta, Jason M., et al.
Publicado: (2012)

Molecular targeting in acute myeloid leukemia
por: Lim, Seah H., et al.
Publicado: (2017)

Sex-based differences in veterans with pulmonary hypertension: Results from the veterans affairs-clinical assessment reporting and tracking database
por: Ventetuolo, Corey E., et al.
Publicado: (2017)

Potential biomarkers to detect traumatic brain injury by the profiling of salivary extracellular vesicles
por: Cheng, Yan, et al.
Publicado: (2019)

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells
por: Mulvey, Hillary E., et al.
Publicado: (2015)

Reply to Helgeson et al.: Remote 6-minute-Walk Testing in Patients with Pulmonary Hypertension: Further Validation Needed?
por: LaPatra, Tess, et al.
Publicado: (2022)

Nanocarriers as treatment modalities for hypertension
por: Alam, Tausif, et al.
Publicado: (2017)

Elucidation of Novel Therapeutic Targets for Acute Myeloid Leukemias with RUNX1-RUNX1T1 Fusion
por: Yun, Jae Won, et al.
Publicado: (2019)

Sexual health and health-related quality of life among women with pulmonary arterial hypertension
por: Banerjee, Debasree, et al.
Publicado: (2018)

Proximity proteomics reveals role of Abelson interactor 1 in the regulation of TAK1/RIPK1 signaling
por: Petersen, Max, et al.
Publicado: (2023)

Epigenetic inactivation of RUNX3 in colorectal cancer
por: Shin, Eung Jin, et al.
Publicado: (2018)

RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner
por: Abdallah, Mohamed Gaber, et al.
Publicado: (2021)

COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis
por: Poor, Hooman D., et al.
Publicado: (2020)

COVID-19 Critical Illness Pathophysiology Driven by Diffuse Pulmonary Thrombi and Pulmonary Endothelial Dysfunction Responsive to Thrombolysis
por: Poor, Hooman D., et al.
Publicado: (2020)

Identifying Patients with Pulmonary Arterial Hypertension Using Administrative Claims Algorithms
por: Mathai, Stephen C., et al.
Publicado: (2019)

Cells Capable of Bone Production Engraft from Whole Bone Marrow Transplants in Nonablated Mice
por: Nilsson, Susan K., et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_82d85p4l8nvlofgkk213l77efr