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PHLPP1 deficiency protects against age‐related intervertebral disc degeneration

BACKGROUND: Intervertebral disc (IVD) degeneration is strongly associated with low back pain and is highly prevalent in the elderly population. Hallmarks of IVD degeneration include cell loss and extracellular matrix degradation. The PH domain leucine‐rich‐repeats protein phosphatase (PHLPP1) is hig...

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Detalles Bibliográficos
Autores principales: Zhang, Changli, Joseph, Katherine M., Khan, Nazir M., Diaz‐Hernandez, Martha Elena, Drissi, Hicham, Illien‐Junger, Svenja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799085/
https://www.ncbi.nlm.nih.gov/pubmed/36601379
http://dx.doi.org/10.1002/jsp2.1224