A novel method for in silico assessment of Methionine oxidation risk in monoclonal antibodies: Improvement over the 2-shell model

Over the past decade, therapeutic monoclonal antibodies (mAbs) have established their role as valuable agents in the treatment of various diseases ranging from cancers to infectious, cardiovascular and autoimmune diseases. Reactive groups of the amino acids within these proteins make them susceptibl...

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Detalles Bibliográficos
Autores principales: Tavella, Davide, Ouellette, David R., Garofalo, Raffaella, Zhu, Kai, Xu, Jianwen, Oloo, Eliud O., Negron, Christopher, Ihnat, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799309/
https://www.ncbi.nlm.nih.gov/pubmed/36580468
http://dx.doi.org/10.1371/journal.pone.0279689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799309/
https://www.ncbi.nlm.nih.gov/pubmed/36580468
http://dx.doi.org/10.1371/journal.pone.0279689

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