Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization

Prescription of PCSK9-inhibitors has increased in recent years but not much is known about its off-target effects. PCSK9-expression is evident in non-hepatic tissues, notably the brain, and genetic variation in the PCSK9 locus has recently been shown to be associated with mood disorder-related trait...

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Detalles Bibliográficos
Autores principales: Aman, Alisha, Slob, Eric A. W., Ward, Joey, Cullen, Breda, Graham, Nicholas, Lyall, Donald M., Sattar, Naveed, Strawbridge, Rona J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799310/
https://www.ncbi.nlm.nih.gov/pubmed/36580462
http://dx.doi.org/10.1371/journal.pone.0279381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799310/
https://www.ncbi.nlm.nih.gov/pubmed/36580462
http://dx.doi.org/10.1371/journal.pone.0279381

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