Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined. Here, we demonstrate that DCX negatively regulates dynein-mediated retrograde transport in n...

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Detalles Bibliográficos
Autores principales: Fu, Xiaoqin, Rao, Lu, Li, Peijun, Liu, Xinglei, Wang, Qi, Son, Alexander I, Gennerich, Arne, Liu, Judy Shih-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799976/
https://www.ncbi.nlm.nih.gov/pubmed/36476638
http://dx.doi.org/10.7554/eLife.82218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799976/
https://www.ncbi.nlm.nih.gov/pubmed/36476638
http://dx.doi.org/10.7554/eLife.82218

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