Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene

INTRODUCTION: DYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome (DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive phenotypes, and aging. Dyrk1A has also been implicated in cerebellar abnormalities observed in association with DS, and...

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Detalles Bibliográficos
Autores principales: Ortega, Mireia, De Toma, Ilario, Fernández-Blanco, Álvaro, Calderón, Anna, Barahona, Lucía, Trullàs, Ramón, Sabidó, Eduard, Dierssen, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800213/
https://www.ncbi.nlm.nih.gov/pubmed/36590914
http://dx.doi.org/10.3389/fnmol.2022.1015220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800213/
https://www.ncbi.nlm.nih.gov/pubmed/36590914
http://dx.doi.org/10.3389/fnmol.2022.1015220

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