Depletion of HIV reservoir by activation of ISR signaling in resting CD4(+) T cells

HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4(+) T cell model of latency without effect on HIV-negative CD4(+) T...

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Detalles Bibliográficos
Autores principales: Li, Dajiang, Wong, Lilly M., Tang, Yuyang, Allard, Brigitte, James, Katherine S., Thompson, George R., Dandekar, Satya, Browne, Edward P., Li, Qingsheng, Simon, Jeremy M., Archin, Nancie M., Margolis, David M., Jiang, Guochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800255/
https://www.ncbi.nlm.nih.gov/pubmed/36590168
http://dx.doi.org/10.1016/j.isci.2022.105743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800255/
https://www.ncbi.nlm.nih.gov/pubmed/36590168
http://dx.doi.org/10.1016/j.isci.2022.105743

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