Polycytidine tract deletion from microRNA-detargeted oncolytic Mengovirus optimizes the therapeutic index in a murine multiple myeloma model

Mengovirus is an oncolytic picornavirus whose broad host range allows for testing in immunocompetent cancer models. Two pathogenicity-ablating approaches, polycytidine (polyC) tract truncation and microRNA (miRNA) targets insertion, eliminated the risk of encephalomyocarditis. To investigate whether...

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Detalles Bibliográficos
Autores principales: Penza, Velia, Maroun, Justin W., Nace, Rebecca A., Schulze, Autumn J., Russell, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800256/
https://www.ncbi.nlm.nih.gov/pubmed/36619293
http://dx.doi.org/10.1016/j.omto.2022.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800256/
https://www.ncbi.nlm.nih.gov/pubmed/36619293
http://dx.doi.org/10.1016/j.omto.2022.11.006

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