IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to IL7. We found that rs16906...

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Detalles Bibliográficos
Autores principales: Taylor, Chelsea A., Watson, Robert A., Tong, Orion, Ye, Weiyu, Nassiri, Isar, Gilchrist, James J., de los Aires, Alba Verge, Sharma, Piyush Kumar, Koturan, Surya, Cooper, Rosalin A., Woodcock, Victoria K., Jungkurth, Elsita, Shine, Brian, Coupe, Nicholas, Payne, Miranda J., Church, David N., Naranbhai, Vivek, Groha, Stefan, Emery, Paul, Mankia, Kulveer, Freedman, Matthew L., Choueiri, Toni K., Middleton, Mark R., Gusev, Alexander, Fairfax, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800275/
https://www.ncbi.nlm.nih.gov/pubmed/36526722
http://dx.doi.org/10.1038/s41591-022-02095-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800275/
https://www.ncbi.nlm.nih.gov/pubmed/36526722
http://dx.doi.org/10.1038/s41591-022-02095-5

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