Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT(2C)R) in weight regulation and behavior. Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without...

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Detalles Bibliográficos
Autores principales: He, Yang, Brouwers, Bas, Liu, Hesong, Liu, Hailan, Lawler, Katherine, Mendes de Oliveira, Edson, Lee, Dong-Kee, Yang, Yongjie, Cox, Aaron R., Keogh, Julia M., Henning, Elana, Bounds, Rebecca, Perdikari, Aliki, Ayinampudi, Vikram, Wang, Chunmei, Yu, Meng, Tu, Longlong, Zhang, Nan, Yin, Na, Han, Junying, Scarcelli, Nikolas A., Yan, Zili, Conde, Kristine M., Potts, Camille, Bean, Jonathan C., Wang, Mengjie, Hartig, Sean M., Liao, Lan, Xu, Jianming, Barroso, Inês, Mokrosinski, Jacek, Xu, Yong, Sadaf Farooqi, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800280/
https://www.ncbi.nlm.nih.gov/pubmed/36536256
http://dx.doi.org/10.1038/s41591-022-02106-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800280/
https://www.ncbi.nlm.nih.gov/pubmed/36536256
http://dx.doi.org/10.1038/s41591-022-02106-5

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