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THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate
THOC5, a member of the THO complex, is essential for the 3′processing of some inducible genes, the export of a subset of mRNAs and stem cell survival. Here we show that THOC5 depletion results in altered 3′cleavage of >50% of mRNAs and changes in RNA polymerase II binding across genes. THOC5 is r...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800341/ https://www.ncbi.nlm.nih.gov/pubmed/36590164 http://dx.doi.org/10.1016/j.isci.2022.105784 |