THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

THOC5, a member of the THO complex, is essential for the 3′processing of some inducible genes, the export of a subset of mRNAs and stem cell survival. Here we show that THOC5 depletion results in altered 3′cleavage of >50% of mRNAs and changes in RNA polymerase II binding across genes. THOC5 is r...

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Detalles Bibliográficos
Autores principales: Polenkowski, Mareike, Allister, Aldrige Bernardus, Burbano de Lara, Sebastian, Pierce, Andrew, Geary, Bethany, El Bounkari, Omar, Wiehlmann, Lutz, Hoffmann, Andrea, Whetton, Anthony D., Tamura, Teruko, Tran, Doan Duy Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800341/
https://www.ncbi.nlm.nih.gov/pubmed/36590164
http://dx.doi.org/10.1016/j.isci.2022.105784

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