The role of mitochondria in pharmacological ascorbate-induced toxicity

At pharmacological levels, ascorbate (P-AscH(-)) acts as a pro-oxidant by generating H(2)O(2), depleting ATP in sensitive cells leading to cell death. The aim of this study was to determine the role of ATP production by oxidative phosphorylation or glycolysis in mechanisms of resistance to P-AscH(–)...

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Detalles Bibliográficos
Autores principales: Du, Juan, Pope, Amanda N., O’Leary, Brianne R., Wagner, Brett A., Goswami, Prabhat C., Buettner, Garry R., Cullen, Joseph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800562/
https://www.ncbi.nlm.nih.gov/pubmed/36581766
http://dx.doi.org/10.1038/s41598-022-27185-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800562/
https://www.ncbi.nlm.nih.gov/pubmed/36581766
http://dx.doi.org/10.1038/s41598-022-27185-9

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