Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer

Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic allelic imbalances (AIs) has been limited by methods focused on BRCA1/2 mutations and using mixtures of cancer types. Us...

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Detalles Bibliográficos
Autores principales: Perez-Villatoro, Fernando, Oikkonen, Jaana, Casado, Julia, Chernenko, Anastasiya, Gulhan, Doga C., Tumiati, Manuela, Li, Yilin, Lavikka, Kari, Hietanen, Sakari, Hynninen, Johanna, Haltia, Ulla-Maija, Tyrmi, Jaakko S., Laivuori, Hannele, Konstantinopoulos, Panagiotis A., Hautaniemi, Sampsa, Kauppi, Liisa, Färkkilä, Anniina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800569/
https://www.ncbi.nlm.nih.gov/pubmed/36581696
http://dx.doi.org/10.1038/s41698-022-00339-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800569/
https://www.ncbi.nlm.nih.gov/pubmed/36581696
http://dx.doi.org/10.1038/s41698-022-00339-8

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