High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells

NLRP1 is the primary inflammasome sensor in human keratinocytes. Sensing of UVB radiation by NLRP1 is believed to underlie the induction of sunburn. Although constitutive NLRP1 activation causes skin inflammation and predisposes patients to the development of cutaneous SCCs, the NLRP1 pathway is sup...

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Detalles Bibliográficos
Autores principales: Hennig, Paulina, Di Filippo, Michela, Bilfeld, Gilles, Mellett, Mark, Beer, Hans-Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800582/
https://www.ncbi.nlm.nih.gov/pubmed/36581625
http://dx.doi.org/10.1038/s41419-022-05530-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800582/
https://www.ncbi.nlm.nih.gov/pubmed/36581625
http://dx.doi.org/10.1038/s41419-022-05530-0

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