p21 induces a senescence program and skeletal muscle dysfunction

Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes to cellular senescence and pathological features i...

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Detalles Bibliográficos
Autores principales: Englund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A., Chini, Eduardo N., Baker, Darren J., van Deursen, Jan M., LeBrasseur, Nathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800630/
https://www.ncbi.nlm.nih.gov/pubmed/36509362
http://dx.doi.org/10.1016/j.molmet.2022.101652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800630/
https://www.ncbi.nlm.nih.gov/pubmed/36509362
http://dx.doi.org/10.1016/j.molmet.2022.101652

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