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Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting
Rationale: Nanobodies (Nbs) have emerged as an elegant alternative to the use of conventional monoclonal antibodies in cancer therapy, but a detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers is lacking. This is especially relevant for the recogni...
Autores principales: | Erreni, Marco, D'Autilia, Francesca, Avigni, Roberta, Bolli, Evangelia, Arnouk, Sana M., Movahedi, Kiavash, Debie, Pieterjan, Anselmo, Achille, Parente, Raffaella, Vincke, Cécile, van Leeuwen, Fijs W.B., Allavena, Paola, Garlanda, Cecilia, Mantovani, Alberto, Doni, Andrea, Hernot, Sophie, Van Ginderachter, Jo A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800720/ https://www.ncbi.nlm.nih.gov/pubmed/36593955 http://dx.doi.org/10.7150/thno.77560 |
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