cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus

INTRODUCTION: Type I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated type I IFN production. The activation of STING induces lupus disea...

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Detalles Bibliográficos
Autores principales: Kumpunya, Sarinya, Thim-uam, Arthid, Thumarat, Chisanu, Leelahavanichkul, Asada, Kalpongnukul, Nuttiya, Chantaravisoot, Naphat, Pisitkun, Trairak, Pisitkun, Prapaporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800982/
https://www.ncbi.nlm.nih.gov/pubmed/36591278
http://dx.doi.org/10.3389/fimmu.2022.1010764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800982/
https://www.ncbi.nlm.nih.gov/pubmed/36591278
http://dx.doi.org/10.3389/fimmu.2022.1010764

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