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cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus

INTRODUCTION: Type I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated type I IFN production. The activation of STING induces lupus disea...

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Detalles Bibliográficos
Autores principales:	Kumpunya, Sarinya, Thim-uam, Arthid, Thumarat, Chisanu, Leelahavanichkul, Asada, Kalpongnukul, Nuttiya, Chantaravisoot, Naphat, Pisitkun, Trairak, Pisitkun, Prapaporn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800982/ https://www.ncbi.nlm.nih.gov/pubmed/36591278 http://dx.doi.org/10.3389/fimmu.2022.1010764

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