Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

CD3-targeted lentiviral vectors (CD3-LVs) mediate selective transduction of human T lymphocytes in vitro and in vivo while simultaneously activating the targeted cells. Previously, we have demonstrated that CD3-LV leads to downmodulation of the CD3:T cell receptor (TCR) complex. We therefore hypothe...

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Detalles Bibliográficos
Autores principales: Braun, Angela H., Frank, Annika M., Ho, Naphang, Buchholz, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801082/
https://www.ncbi.nlm.nih.gov/pubmed/36620073
http://dx.doi.org/10.1016/j.omtm.2022.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801082/
https://www.ncbi.nlm.nih.gov/pubmed/36620073
http://dx.doi.org/10.1016/j.omtm.2022.12.002

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