Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation

Aggregated α-synuclein (α-syn) accumulates in the neuronal Lewy body (LB) inclusions in Parkinson's disease (PD) and LB dementia. Yet, under nonpathological conditions, monomeric α-syn is hypothesized to exist in an equilibrium between disordered cytosolic- and partially α-helical lipid-bound s...

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Detalles Bibliográficos
Autores principales: Reimer, Lasse, Gram, Hjalte, Jensen, Nanna Møller, Betzer, Cristine, Yang, Li, Jin, Lorrain, Shi, Min, Boudeffa, Driss, Fusco, Giuliana, De Simone, Alfonso, Kirik, Deniz, Lashuel, Hilal A, Zhang, Jing, Jensen, Poul Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802061/
https://www.ncbi.nlm.nih.gov/pubmed/36712380
http://dx.doi.org/10.1093/pnasnexus/pgac259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802061/
https://www.ncbi.nlm.nih.gov/pubmed/36712380
http://dx.doi.org/10.1093/pnasnexus/pgac259

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