Acylation driven by intracellular metabolites in host cells inhibits Cas9 activity used for genome editing

CRISPR-Cas, the immune system of bacteria and archaea, has been widely harnessed for genome editing, including gene knockouts and knockins, single-base editing, gene activation, and silencing. However, the molecular mechanisms underlying fluctuations in the genome editing efficiency of crispr in var...

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Detalles Bibliográficos
Autores principales: Zhao, Li, You, Di, Wang, Ting, Zou, Zhen-Ping, Yin, Bin-Cheng, Zhou, Ying, Ye, Bang-Ce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802096/
https://www.ncbi.nlm.nih.gov/pubmed/36712324
http://dx.doi.org/10.1093/pnasnexus/pgac277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802096/
https://www.ncbi.nlm.nih.gov/pubmed/36712324
http://dx.doi.org/10.1093/pnasnexus/pgac277

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