Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease

BACKGROUND: Thiopurine methyltransferase (TPMT) activity influences azathioprine conversion into active metabolite 6-thioguanine nucleotide (6-TGN). Low TPMT activity correlates with high 6-TGN and risk for myelosuppression. Conversely, normal-to-high TPMT activity may be associated with low 6-TGN a...

Descripción completa

Detalles Bibliográficos
Autores principales: Jonason, David E, Sievers, Tyson, Trocke, Lindsay, Abraham, James M, Vaughn, Byron P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802184/
https://www.ncbi.nlm.nih.gov/pubmed/36776499
http://dx.doi.org/10.1093/crocol/otaa058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802184/
https://www.ncbi.nlm.nih.gov/pubmed/36776499
http://dx.doi.org/10.1093/crocol/otaa058

Ejemplares similares